What is pseudohypoparathyroidism type 1B?
Pseudohypoparathyroidism type 1B (PHP1B) is a disorder characterized by lack of response (resistance) to parathyroid hormone (PTH) and other hormones such as thyroid-stimulating hormone (TSH).
What is pseudohypoparathyroidism Type 1A?
Overview. Pseudohypoparathyroidism type 1A (PHP1A) is a type of pseudohypoparathyroidism. Pseudohypoparathyroidism occurs when your body is unable to respond to parathyroid hormone, a hormone that controls the levels of calcium, phosphorous, and vitamin D in the blood.
What is the difference between pseudohypoparathyroidism and pseudo Pseudohypoparathyroidism?
Pseudopseudohypoparathyroidism and pseudohypoparathyroidism both involve the same GNAS gene, but Pseudopseudohypoparathyroidism has normal calcium homeostasis because of the normal maternal allele in the kidney.
What does pseudohypoparathyroidism mean?
Pseudohypoparathyroidism is a hereditary disorder characterized by an inadequate response to the parathyroid hormone, although the hormone is present in normal amounts. This inadequate response affects bone growth in individuals with Pseudohypoparathyroidism.
What are symptoms of PHP?
- Dental problems.
- Tetany (a collection of symptoms including muscle twitches and hand and foot cramps and muscle spasms)
What is GNAS mutation?
GNAS mutations cause developmental delay, short stature, and skeletal abnormalities in a syndrome called Albright’s hereditary osteodystrophy. Because of imprinting, mutations on the maternal allele also cause obesity and hormone resistance (pseudohypoparathyroidism).
How many cases of pseudohypoparathyroidism are there?
Pseudohypoparathyroidism is a very rare disorder, with estimated prevalence between 0.3 and 1.1 cases per 100000 population depending on geographic location.
How do you test for pseudohypoparathyroidism?
Laboratory studies for the diagnosis of pseudohypoparathyroidism (PHP) include serum calcium tests (including measurement of serum total calcium and ionized calcium) to confirm a hypocalcemic state. Serum phosphate levels are elevated in PHP.
Is pseudohypoparathyroidism same as secondary hyperparathyroidism?
Some of the biochemical features of secondary hyperparathyroidism (e.g., hypocalcemia, elevated serum PTH) can also be seen in pseudohypoparathyroidism, a syndrome of resistance to the biochemical actions of PTH.
What are causes of PHP?
Primary hyperparathyroidism (PHP) is a disease caused by excessive production of parathyroid hormone (PTH). This can be due to a tumor of one or more of the parathyroid glands or to a condition called hyperplasia in which all four of the parathyroid glands are enlarged and overproduce PTH (about 10% of cases).
How do you treat pseudohypoparathyroidism?
All patients with severe symptomatic hypocalcemia should be initially treated with intravenous calcium. Administration of oral calcium and 1alpha-hydroxylated vitamin D metabolites, such as calcitriol, remains the mainstay of treatment and should be initiated in every patient with a diagnosis of PHP.
Does hypoparathyroidism cause weight gain?
Hyperparathyroidism patients sometimes experience chronic fatigue, which makes them less active and more prone to weight gain. Conversely, if a parathyroid tumor is removed, the body is better equipped than ever before to maintain consistent calcium levels.
What Can PHP Do?
What Can PHP Do?
- PHP can generate dynamic page content.
- PHP can create, open, read, write, delete, and close files on the server.
- PHP can collect form data.
- PHP can send and receive cookies.
- PHP can add, delete, modify data in your database.
- PHP can be used to control user-access.
- PHP can encrypt data.