What does it mean if your ANA is speckled?
Homogenous (diffuse) pattern suggests SLE or other connective tissue diseases. Speckled pattern correlates with antibody to nuclear antigens extractable by saline; it is found in many disease states, including SLE and scleroderma.
Can you have a speckled ANA and not have lupus?
A positive ANA does not by itself diagnose lupus since about 10% of normal people and many people with other autoimmune diseases, such as thyroid disease, also have positive tests, but usually less strongly positive. Once positive, an ANA mostly stays positive, so need not be repeated.
Is speckled ANA rare?
Identification of ANA subtypes plays a key role in diagnosis of specific CTD. The present study verified the profile of patient samples tested for ENA antibodies and correlated the ENA results with ANA patterns. The most common pattern was speckled S-ANA (32.4%) in females and homologous H-ANA pattern (25.4%) in males.
What does speckled ANA 1 80 mean?
The ANA test is used specifically for the diagnosis of systemic lupus erythematosis (SLE). A positive ANA titer (> 1:80) with the associated clinical signs (e.g. skin disease, polyarthritis) and laboratory findings (e.g. proteinuria, thrombocytopenia) is diagnostic for SLE.
How common is speckled ANA?
The most frequent ANA patterns were coarse speckled pattern (154 patients, 31.2%), nucleolar pattern (89 patients, 18.0%), fine speckled pattern (57 patients, 11.5%), and speckled pattern (48 patients, 9.7%).
Can speckled ANA be false positive?
The ANA test is very sensitive for the diagnosis of autoimmune diseases but results in many false positives. It has been reported that up to 15% of completely healthy individuals have a positive ANA test without an autoimmune disease and that ANAs are measurable in approximately 25% of the population.
What does an ANA titer of 1 160 speckled mean?
We suggest that ANA tests showing speckled pattern should be at a 1:160 titer or higher to be considered positive; other patterns such as homogeneous, peripheral, or centromeric might be considered positive even at low titers (
Does speckled ANA always mean autoimmune disease?
However, a positive result doesn’t always mean that you have an autoimmune disease. Up to 15 percent of completely healthy people have a positive ANA test. This is called a false-positive test result.
What does ANA titer 1 640 speckled mean?
Because more than 30% of normal individuals have been found to have low ANA titers,5 the patients with negative or positive results at a titer of 1:40 were excluded. In our laboratory, an ANA titer of 1:640 is defined as a “high titer” because of a 0.5% prevalence of positives in normal individuals.
What does ANA titer 1 320 speckled mean?
If the ANA titre is high (e.g. 1:640, 1:1280 or 1:2560), this indicates more severe disease. If the ANA titre is low (e.g. 1:40, 1:80 or even 1:160), there is often no autoimmune disease. If the ANA titre is in the middle (e.g. 1:320), the result is less clear and should be interpreted in the clinical context.
Is a titer of 1 160 high speckled?
What does a positive ANA 1/160 with speckled pattern mean?
What does a positive ANA 1:160 with speckled pattern mean? Not much by itself: An ANA of 1:160 is a low titter and can be seen in healthy people. The speckled pattern is commonly associated with lupus but is not enough to make a diagnosis especially when the titer is very low.
What does it mean if your Ana is positive?
Often nothing: The ANA is not very specific. It can be positive in numerous diseases including viral diseases. It can also be positive in individuals without any disease. The ANA needs to be interpreted in the clinical setting to be properly evaluated. An ANA of only 1:80 is borderline at most.
What are the diseases associated with Ana?
These diseases include: ● Gastrointestinal diseases (autoimmune hepatitis, primary biliary cholangitis [also known as primary biliary cirrhosis], inflammatory bowel disease) Patients with infectious diseases may also test positive for ANA.