Can proton pump inhibitors cause dementia?
Objectives. Proton pump inhibitors (PPIs) are commonly prescribed for prevention and treatment of gastrointestinal conditions or for gastroprotection from other drugs. Research suggests they are linked to increased dementia risk.
Do acid reducers cause dementia?
WEDNESDAY, June 28, 2017 (HealthDay News) — Drugs used to treat acid reflux and ulcers don’t appear to boost the risk of dementia, as has been previously suspected, new research suggests.
Is there a link between omeprazole and dementia?
Three studies have found a positive association between dementia and omeprazole, esomeprazole, lansoprazole, and pantropazole, with an approximately 1.4-fold increased risk of any dementia in cohorts using PPIs (95% CI, 1.36–1.52; P < 0.001) .
Which acid reflux medicine causes dementia?
Routine use of proton-pump inhibitors (PPIs)—drugs such as Nexium and Prilosec, used to treat heartburn, gastroesophageal reflux disease or peptic ulcers—may cause or accelerate dementia in elderly individuals.
Do proton pump inhibitors cause Alzheimer’s?
“We’ve been able to show that proton pump inhibitors affect the synthesis of the neurotransmitter acetylcholine, which plays a significant part in conditions such as Alzheimer’s disease,” says Taher Darreh-Shori, PhD, senior researcher at the department of neurobiology, care sciences and society.
Is there an alternative to PPI medication?
These include proton pump inhibitors such as esomeprazole (Nexium), omeprazole (Prilosec), pantoprazole (Protonix) and lansoprazole (Prevacid). The others are antacids such as Maalox, Mylanta and Tums; and H2 (histamine) receptor antagonists such as famotidine (Pepcid), and cimetidine (Tagamet).
What are the side effects of long term use of proton pump inhibitors?
Although PPIs have had an encouraging safety profile, recent studies regarding the long-term use of PPI medications have noted potential adverse effects, including risk of fractures, pneumonia, Clostridium difficile diarrhea, hypomagnesemia, vitamin B12 deficiency, chronic kidney disease, and dementia.
What are the long-term effects of proton pump inhibitors?
Why you shouldn’t take proton pump inhibitors?
Recent studies, however, have cited dangers thought to be associated with the long-term use of PPIs. Among them: an increased risk of kidney disease, osteoporosis, low magnesium or vitamin B12 in the blood, pneumonia, stroke, and contracting the Clostridium difficile (C. diff) bacterium.
What can I use instead of PPI?
Although PPIs were found to be more effective in treating symptoms and complications associated with GERD, H2 blockers have proven to be just as effective in suppressing gastric acid. H2 blockers are available by prescription or over-the-counter, and include ranitidine, famotidine, cimetidine and nizatidine.
What is the safest acid reflux medicine for long-term use?
Proton pump inhibitors are accepted as the most effective initial and maintenance treatment for GERD. Oral pantoprazole is a safe, well tolerated and effective initial and maintenance treatment for patients with nonerosive GERD or erosive esophagitis.